The Sacristy of the Basilica of San Domenico Maggiore, with a rectangular plan, is decorated in Baroque style as designed in the early years of the eighteenth century by Giovan Battista Nauclerio. The environment, finely decorated on the walls with wooden walnut stalls made by the master Domenico Russo on drawings of Nauclerio, presents on the vault the sumptuous fresco of the Triumph of faith on heresy by the Dominicans made by Francesco Solimena in 1709, an absolute pictorial masterpiece.
On the floor, near the entrance door, there is the tombstone of Richard Luke Concanen, the first Catholic bishop of New York who died in Naples in 1810, while near the left side door there is a fourteenth-century bas-relief depicting Mary Magdalene.
On the back wall is the Cappella Milano, also known as the Chapel of the Annunciation because of the theme represented in the altarpiece by Fabrizio Santafede (1560-1634). The latter surmounts the elegant high altar by Bartolomeo and Pietro Ghetti, datable between 1624 and 1626, while on the two side walls there are two frescoes depicting important members of the Milano family painted by Giacomo Del Po before 1715.
