The Palace of the Princes of Migliano, De Vargas-Machuca, is located on the edge of the village of San Giovanni, outside the city walls.
The building has a composite façade, mixed between the neoclassical portal, whose balcony above is visible the stucco coat of arms of the princely family. The windows have a clear neo-Gothic style.
This was the residence of Michele De Vargas-Machuca who had inherited the title from his wife Maria Concetta del Tufo, granddaughter of Lavinia Cervone Vernieri.
Michele De Vargas-Machuca held the position of Mayor of the city and celebrated the fiftieth anniversary of the Unification of Italy.
The activity that distinguished him was that of having held the role in the Chamber of Deputies during the XXIV legislature, from 1913 to 1919.
The palace hosted the Crown Prince of Italy Umberto di Savoia when he went to the nearby Palace of Persano on the occasions when national horse races were held.