The Chapel of Santa Maria dei Pignatelli, located in the historical centre of Naples, is considered an important artistic and architectural masterpiece of the Renaissance period and has been closed to the public for over fifty years. At the end of the 60s it had even become an illegal deposit of chairs. The Chapel is one of the rarest caskets of Renaissance Naples, which stands right in the heart of the ancient Neapolitan centre, at Largo Corpo di Napoli, lined up along the lower decumanus of the Greco-Roman city, where Piazzetta Nilo and San Biagio dei Librai intersect.