In Piazza Duomo stands the city’s most important religious building, St. Mark’s Cathedral in Pordenone. The building, dedicated to the patron saint of Pordenone, was built between the thirteenth and fifteenth centuries. Its Romanesque-Gothic style was, over time, affected by different elements such as the neoclassical facade, the result of a nineteenth-century remake remained unfinished, and the Renaissance portal, a sixteenth-century work by Giovanni Antonio Pilacorte.
The bell tower, completed in 1347, is 72 m high and is made entirely of brick, with elegant friezes, a square plan and a belfry larger than the base. The interior of St. Mark’s Cathedral in Pordenone, with a single nave and side chapels, preserves a masterpiece of Venetian art, the "Pala della Misericordia" (Altarpiece of Mercy) by Giovanni Antonio De’ Sacchis, known as Pordenone. The side chapels were added in the 16th century. Of particular note is the Ricchieri Chapel, dedicated to Saints Peter and Paul and frescoed with 15th-century images of saints, angels, city views and symbols of the Evangelists, the Chapel of St. Nicholas, whose frescoes tell the stories of the saint and the Doctors of the Church, and the Mantica Chapel, with a cycle of frescoes from 1554 by Giovanni Maria Zaffoni, known as Calderari. The holy water stoup and the baptismal font are works by Pilacorte.