The Synagogue was built in 1595 undergoing, over the centuries, enlargements and renovations: today it presents itself in its Baroque rococo Piedmontese splendor (1700-1800) enhanced by a careful restoration. Externally, it is of no artistic interest: until the Albertine Statute, in fact, it was forbidden for Jews to build facade decorations for the Temple; but as soon as the visitor crosses the threshold, he can only be enchanted by the richness of gold, stuccoes, inscriptions in Hebrew to testify the centuries of life of the community of Casale Monferrato.
The matroneum houses the Museo degli Argenti, one of the most interesting museums of Jewish art and history in Europe: numerous silverware, textiles and objects of worship allow the visitor to grasp the spirit and integration of Jewish culture. It is flanked by the Museum of Enlightenment, with candelabra of contemporary art.