If you love art, this total immersion in one of the world’s largest museums will not let you down. The 50 galleries house the most significant masterpieces by artists such as Da Vinci, Raphael and Bellini, to name but a few. The visit of the museum ends with the descent of Bramante’s famous spiral staircase, in the Pio Clementino Museum, before moving on to the Sistine Chapel, which houses the marvellous frescoes painted by Michelangelo in the 16th century, including the Creation of Adam.